Blood Donations in U.S. Testing Positive for Chagas' Disease

In the 10 months since the U.S. Food and Drug Administration licensed the first blood-screening test for Chagas' disease, some 241 blood donations in the United States have tested positive, indicating donor exposure to the parasite known to cause this serious and potentially fatal parasitic infection, according to data released today at the annual meeting of American Association of Blood Banks (AABB). The test is manufactured by Ortho-Clinical Diagnostics, Inc.

Chagas'-positive donations have been reported in 34 states with the highest concentration in California, Florida and Texas, according to data compiled by the AABB.

Also called American trypanosomiasis, Chagas' disease is an infection caused by the blood-borne parasite Trypanosoma cruzi, or T.cruzi. The disease is endemic to most countries in Central and South America, as well as Mexico. Transmission occurs through insect bites, blood transfusions, organ transplants and via infected pregnant women to children in utero.

Early infection is usually mild and unrecognized, but persists lifelong and may lead to organ damage, particularly of the heart and esophagus, causing an estimated 50,000 deaths annually worldwide. Infection also can be severe in people whose immune systems are suppressed, such as organ transplant recipients.

During presentations at the conference today, blood safety experts also say they are investigating new cases of transmissions of Chagas' disease that may have occurred through blood transfusions and via insect bites from bugs known to carry the parasite. Such cases have been extremely rare, or have gone undocumented, in the United States. Dr. Susan Stramer, executive scientific officer for the America Red Cross, says blood safety experts are
investigating 20 cases of possible insect-to-human transmissions with strong evidence suggesting that nine cases may have occurred in the U.S. Also, the Red Cross is investigating four possible transmissions via blood transfusions. Details of these cases were not disclosed.

"While we have known that Chagas' disease was present in North America, the numbers of Chagas'-positive blood donations, as well as new reports of transmission of infection to persons from bugs, are surprising," says Dr. James Maguire, M.D., director, International Health Division, University of Maryland School of Medicine. Maguire is the former chief of the parasitic
diseases branch at the U.S. Centers for Disease Control and Prevention (CDC).

The American Red Cross was among the first blood collection agencies in the U.S. to begin testing donations for Chagas' in late January, following FDA approval of Ortho's blood-screening test in December 2006. Today, approximately 70 percent of all blood donations in the U.S. are now being screened for Chagas'.

In additional developments, public health authorities in the state of Arizona have made Chagas' a "reportable" disease. Three southern states are considering similar action. A reportable disease is one that must be reported to federal, state, or local health officials when diagnosed --
like active tuberculosis, hepatitis, gonorrhea and HIV, for example.

According to the CDC, as many as 8 to 11 million people in Mexico, Central America and South America have Chagas' disease. Most do not know they are infected. Chagas' disease can be treated successfully if detected soon after the infection occurs, but there is no cure once the
disease has entered the chronic stage.

Watch more breaking news now on our video feed:

Bookmark http://universeeverything.blogspot.com/ and drop back in sometime.