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Study: Health Supplement May Curb Addiction of Problem Gamblers

University of Minnesota researchers have discovered that a common amino acid, available as a health food supplement, may help curb pathological gamblers’ addiction.

In a recent eight-week trial, 27 people were given increasing doses of the amino acid, N-acetyl cysteine, which has an impact on the chemical glutamate – often associated with reward in the brain. At the end of the trial, 60 percent of the participants reported fewer urges to gamble. The research will be published in the Sept.15, 2007 issue of Biological Psychiatry.

“It looks very promising,” says Jon Grant, a University of Minnesota associate professor of psychiatry and principal investigator of the study. “We were able to reduce people’s urges to gamble.”

Those who responded well in the first round of the study were asked to continue to participate in a double-blind study – a testing method where neither the researcher nor subjects know who is in the control group until the study is finished.

Of the 16 who responded to the amino acid the first time around, 13 agreed to continue in the double-blind study (three didn’t want to risk quitting the drug) for an additional six weeks.

About 83 percent who received the supplement, continued to report fewer urges to gamble. Nearly 72 percent of those who took the placebo went back to gambling.

Similar studies using N-acetyl cysteine have shown its ability to curb drug addictions in animals, and a current University of Minnesota study conducted by Grant is investigating whether the drug could help methamphetamine users quit.

“This research could be encouraging for a lot of addictions,” Grant says.

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Therapy for Restless Legs May Trigger Compulsive Gambling

A class of drugs commonly used to treat the neurological disorder restless legssyndrome (RLS) may cause compulsive gambling, researchers say.

Compulsive gambling with extreme losses -- in two cases, greater than $100,000 -- has been tied to the treatment, according to a Mayo Clinic study.

The Mayo Clinic study is the first to describe compulsive gambling in RLS patients who are being treated with medications that stimulate dopamine receptors in the brain. The Mayo Clinic report appeared in the Jan. 23 issue of Neurology.

The extent of this therapy-related compulsive gambling problem is unknown, the researchers say. Apparently, it occurs only in a small number of RLS patients treated with drugs called dopamine agonists. Considering this potential side effect of dopamine agonists, the Mayo Clinic authors suggest that physicians screen all RLS patients for compulsive behaviors while taking a thorough medical history prior to prescribing dopamine agonists. Patients should be monitored closely forsigns of compulsive behaviors once dopamine agonist treatment has begun. The report suggests that the compulsion to gamble worsened with increasing doses of the dopamine agonists.

Pathological gambling is an impulse control disorder. In 2005, Mayo Clinic physicians reported this disorder as a side effect of dopamine agonist therapy in 11 Parkinson disease patients.

"Although pathologic gambling has already been recognized in patients with Parkinson disease who often took high doses of dopamine agonists, the current report suggests that pathological gambling is not restricted to patients with Parkinson disease -- and also can occur at low dosages," says Maja Tippmann-Peikert, M.D., the lead author of the Mayo Clinic report on restless legs syndrome. "Physicians should not only monitor Parkinson disease patients for this behavior but also screen their RLS patients who may be on much lower doses of dopamine agonists."

This includes encouraging the patient, family members and friends to report negative behaviors to the patient's physician, the researchers say.

Fortunately, pathological gambling seems to be reversible when the dose of the dopamine agonist is reduced or the patient is transitioned to an alternative medication, they say. It is crucial that these adjustments are initiated before significant gambling debts develop, and relationships and careers are damaged, they add.


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