Adding Folic Acid to Bread Could Help Fight Against Depression

A unique study by researchers at the University of York and Hull York Medical School has confirmed a link between depression and low levels of folate, a vitamin which comes from vegetables.

In research published in the July edition of the Journal of Epidemiology and Community Health, the York team led by Dr Simon Gilbody, concluded that there was a link between depression and low folate levels, following a review of 11 previous studies involving 15,315 participants.

Last month, the UK Food Standards Agency recommended to UK Health Ministers the introduction of mandatory fortification of either bread or flour with folic acid to prevent neural tube defects, which can result in miscarriage, neonatal death or lifelong disability. The York study suggests that the measure may also help in the fight against depression.

Dr Gilbody says: "Our study is unique in that for the first time all the relevant evidence in this controversial area has been brought together. Although the research does not prove that low folate causes depression, we can now be sure that the two are linked. Interestingly, there is also some trial evidence that suggests folic acid supplements can benefit people with depression. We recommend that large trials should be carried out to further test this suggestion."

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Vitamin Supplements: More Not Necessarily Better

All vitamin supplements are not created equal. In fact, you need to do a little research when it comes to what supplements you should be taking, according to a new report from Harvard Medical School.

The report offers the following advice:

• Look for a seal of approval. Choose products that bear the U.S. Pharmacopeia Dietary Supplement Verification Program (USP-DSVP) mark, which indicates that the manufacturer has complied with certain standards.


• Consider safe levels. All dietary supplements have a "Supplement Facts" label that lists the percentage of the daily value (DV) of each nutrient per serving, as well as the actual amount of each. Multivitamin and multimineral supplements shouldn't exceed 150% of the DV for any nutrient. In fact, for trace minerals, such as iron, fluoride, and zinc, it's safest not to exceed the DV at all.


• Ignore marketing gimmicks. It doesn't matter whether vitamin C is derived from organic rose hips or synthesized in large batches in a laboratory; your body will use the resulting product similarly. Also, if you're not sensitive to specific ingredients, such as wheat, rice, or lactose, there's no need to pay more for allergen-free products.
• Don't pay more for unproven extras. There is virtually no evidence that herbs and other nonvitamin ingredients added to supplements -- such as echinacea, bioflavonoids, and ubiquinone (coenzyme Q10) -- are essential for your health.
• Beware of potentially dangerous interactions. Pay attention to warnings on the label, and tell your doctor and pharmacist what supplements you take.

"Vitamins and Minerals: What you Need to Know" is a 48-page report edited by Meier Stampfer, M.D., Ph.D., professor of epidemiology and nutrition, Harvard School of Public Health.

Also included in the report:

• detailed explanations of each vitamin's and mineral's physiological effects
• the latest recommendations on each vitamin and mineral
• current research on how specific vitamins and minerals affect health
• how to create a healthy and balanced diet.

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